Comparison of Real time PCR and Conventional PCR for Detection of HLA-B27 in Suspected Ankylosing Spondylitis Patients

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ASSOCIATION OF HLA-B27 WITH ANKYLOSING SPONDYLITIS IN ISFAHAN, IRAN

Using a standard microcytotoxicity (NIH) technique of tissue typing, the HLA-B27 antigen was identified in 30 out of 34 patients (HH.2%) with classical ankylosing spondylitis (AS), compared to 6 out of 70 controls (H.6%) (P < 0.005). We also found this antigen in 8 out of 76 (10.5%) patients with non-AS arthritis.

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HLA-B27 and Ankylosing Spondylitis

Ankylosing spondylitis (AS) is a chronic inflammatory disease with potential disabling outcomes. Clinically, patients presented with inflammatory lower back pain, enthesis and alternated buttock pain (van der Linden & van der Heijde, 1998). Bernard Corner (16661698) was the first physician who published the clinical features of AS in his medical thesis (Baker & Weisman, 2006). In the late 19th ...

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HLA B27 and risk of ankylosing spondylitis.

'Noble, W C, and Naidoo, J, British Journal of Dermatology, 1978, 98, 481. 2 Porthouse, A, et al, Lancet, 1976, 1, 20. 3Ayliffe, G A J, et al, Journal of Clinical Pathology, 1977, 30, 40. 4Lacey, R W, Journal of Medical Microbiology, 1971, 4, 73. 5 Selwyn, S, and Chalmers, D, British J3ournal of Dermatology, 1965, 77, 349. 6 British Medical3Journal, 1978, 1, 1573. 7British Medical3Journal, 1977...

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ژورنال

عنوان ژورنال: SSR Institute of International Journal of Life Sciences

سال: 2019

ISSN: 2581-8732,2581-8740

DOI: 10.21276/ssr-iijls.2019.5.4.4